OVERVIEWThe word pharmacokinetics was coined from the Greek work Pharmakon means drugs and poisons.Wargner in 1968 and 1975 defined pharmacokinetics as the temporal trend of the concentrations or quantities of drugs and metabolites in fluids biological, in tissues and excrements, and also of the pharmacological response, and to build adequate models to interpret such data. In pharmacokinetics, data is analyzed using a mathematical representation of a part or the entire organism. Gilbaldi and Levy in 1976 gave a related definition, defining pharmacokinetics as the study of a characterization of the time course of absorption, distribution, metabolism and absorption of drugs. excretion and with the relationship of these processes to the intensity and time course of the therapeutic and adverse effects of drugs. ORIGINS OF THE OBJECT The first attempt to understand what led to pharmacokinetics/pharmacodynamics was first described by Buchanan Andrew in his work "Physiological effects of ether inhalation". Buchanan pointed out that for short inhalations of ether, the speed of recovery was related to the redistribution of ether in the body and went further by calculating the amount of ether inhaled, exhaled and retained during induction with this short-acting anesthetic (Buchanan 1847, Butler, 1913). , Michaelis and Menten published the Michaelis-Menten equation used to describe the kinetics of enzymes, and the equation was used to describe the elimination kinetics of drugs (Michaelis and Menten 1913). Another wonderful work on the origin of the topic is by Swedish researchers. In 1924 Windmark and Tandberg published the equations now known as the (a) one-compartment open model with intravenous bolus injection and multiple doses administered at uniform intervals... ... half of the paper ..... Schaldemose, 1959). Another major contribution to pharmacokinetics during this period was (a) the introduction of the curve-fitting method based on polyexponential equations (Perl, 1960); and (b) introduction of the use of analog computers for fitting and simulating pharmacokinetic data and in building models (Garrett et al, 1960; Wiegand and Taylor, 1960). The first symposium with a title incorporating the term pharmacokinetics was held in Bors - tel, Germany in 1962. The holding of this symposium has been a powerful force that is spreading the pharmacokinetic idea. Experimental verification of Wagner's 1976 articles which suggest that if a group of subjects were administered the same dose of drug by the same route of administration and resulting temporal data on blood concentration were adapted by polyexponential equations with the number statistically optimal of terms per data set