As illustrated by (Dogruel and Karahasan) there is a growing interest in the integration between regional economy and international trade. With the contributions of new economic geography, different dimensions of the obvious regional variation in economic activity and economic growth have been explained on the basis of the importance of location and in terms of geographical proximity. Therefore, the framework demonstrates the fact that identifying the main motivations or obstacles of the regions that somehow influence the decisions of the production units has become an important issue, as they explain (Dogruel and Karahasan). As (Dogruel and Karahasan) continue, the MENA region is made up of economies that have different political preferences. A series of models were constructed and estimated to explore the differentiation of the business environment in the MENA region. The results show that world GDP growth, MENA GDP growth, world export volume growth, and MENA trade volume growth have no substantial effect on industrial value added growth in MENA countries. On the other hand, as (Dogruel and Karahasan) continue, the growth coefficients in national exports and the change in domestic consumption were present in all models. As (Dogruel and Karahasan) point out the financial development which refers to the change in the money supply shows no sign of significance, while the credit taken into account by the private sector is considered one of the most crucial determinants of the improvement of the business environment. Meanwhile, the inflation rate, which was not taken as an explanatory variable with financial development indicators due to possible multi-collinearity problems, shows signs of instability for industrial value added (Dogruel and Karahasan). And, in order to control the effect of oil, two different models have been recognized. Even if oil reserves have no significant effect on the development of the business environment, an increase in fuel exports would have significant effects on the business sector. (Dogruel and Karahasan) conclude by explaining that both internal and external demands, openness, financial deepening, regional and global trends, as well as oil production and oil reserves are factors that would significantly influence the business environment. The static and dynamic panel data models that were calculated portray that both internal and external demand are the most important reasons for the positive progress present in the business environment. The results also showed that inflation reduces the progress of the business sector.