The process of apoptosis is an organism's internal "waste management" process to eliminate its own damaged, unnecessary, and potentially dangerous cells. This is a physiological event (the normal operational activity of a living matter) also known as “programmed cell death” or “cell suicide”. Cells are removed from the body because they are damaged, infected, possibly cancerous, or otherwise not normal. It is a way to prevent infection, eliminate cells that are no longer needed, or stop the spread of cancer or prevent disruption of homeostasis. Say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essay Apoptosis occurs as an orderly process by which the target cell is condensed or disassembled and then removed from the body by the immune system. Cytotoxic T cells are activated and trigger the process in which the affected cell shrinks and forms blisters (bulges in the plasma membrane). Proteins activated by apoptosis destroy the cell. The enzymes break down the nucleus and signal macrophages (large white blood cells that engulf the cell and use enzymes to destroy it) to remove cellular components from the body. Surrounding cells and tissues are not damaged in the process. No interventions are necessary for apoptosis: it is a normal and necessary body function that does not cause damage to the body. Necrosis (which can be viewed as “cell homicide), unlike apoptosis, is a pathological process. While apoptosis can be viewed as “cellular suicide,” necrosis can be described as “mass cellular homicide.” ”. Necrosis is triggered by external factors: damage, infection, or trauma to cells. Apoptosis occurs in selected cells, but necrosis is the swelling, acidosis, and liquefaction (death) of cells en masse causes inflammation and damage to surrounding normal tissue. Unlike apoptosis, which requires no intervention, necrosis causes irreversible damage and requires immediate, aggressive medical treatment to (1) remove the necrotic tissue and (2) uncover and treat the underlying cause. I have been involved in the treatment of several patients with necrosis. Most of the patients treated also had IDDM or NIDDM, which can cause PAD particularly at the lower extremities. Lack of blood flow leads to the formation of diabetic foot ulcers, which then fail to heal (delayed healing is also a complication of DM). The condition progressed to necrosis because the body's vascular system failed to provide sufficient blood flow in and out of the area to support the tissues. It was not uncommon to see patients with uncontrolled diabetes with amputated toes, feet, and even legs. Surgical amputation has its own risks, and the risk of complications from the surgery increases for patients with comorbidities. Treatment includes removing necrotic tissue and pus, preventing the damage from spreading, and managing the conditions that cause necrosis. Thorough cleansing, removal of necrotic tissue and pus, and hygiene are of the utmost importance. Careful, detailed and accurate documentation of the extent of damage, the patient's response to treatment and use of a multidisciplinary approach to management. Maintaining communication with the dietitian, diabetes educator, nurse, doctor and all other healthcare professionals involved in the patient's care can help ensure that the patient can get the.