Several epidemiological studies demonstrate that obesity and related metabolic dysfunctions are associated with an increased incidence and mortality from various types of cancers. It has been shown, for example, that obesity and type 2 diabetes are among the risk factors associated with the onset of colon cancer. Say no to plagiarism. Get a tailor-made essay on 'Why violent video games should not be banned'? Get an original essay Among the new emerging risk factors for the onset of extrahepatic tumors, NAFLD has played an important role in the development of gastrointestinal tract tumors - intestinal tract. Furthermore, NAFLD is strongly associated with features of metabolic syndrome, including obesity, insulin resistance, type 2 diabetes mellitus (T2DM), and dyslipidemia. It is known that among the risk factors for the onset of NAFLD are poor eating habits associated with a sedentary lifestyle, in this case a combination of dietary restrictions associated with physical activity is commonly recommended for people with NAFLD. However, a significant proportion of patients develop NAFLD despite having a normal body mass index (BMI) and some features of metabolic syndrome. Today, lifestyles are increasingly sedentary and NAFLD has quickly become one of the most common causes of liver disease worldwide. NAFLD is a condition closely related to obesity, diabetes and metabolic syndrome. It is often diagnosed following an occasional ultrasound evaluation of the abdomen, but in reality many cases are associated with other metabolic disorders (hypertriglyceridemia, hypercholesterolemia, hypertension), forming the picture of the so-called "metabolic syndrome". it's just an example. Get a custom paper from our expert writers now. Get a Custom Essay Visceral obesity is a major risk factor in the onset of NAFLD. In fact, the prevalence of NAFLD increases with increasing body mass index (BMI). Ectopic fat accumulation, including visceral obesity and fatty liver, can lead to adipose tissue dysfunction resulting in altered adipocytokine levels. One of the key factors in the pathogenesis of NAFLD is determined by insulin resistance (IR) (Figure 1), NAFLD is therefore considered the hepatic component of metabolic syndrome (MS) or IR. The state of chronic low-grade inflammation due to obesity and the presence of NAFLD leads to the emergence of a microenvironment favorable to the development of cancer and the onset of insulin resistance due to the activation of the axis that regulates the growth of insulin- 1 IGF-1 and insulin resulting in hyperinsulinemia. Through its proliferative and anti-apoptotic effects, this process can increase mutations that promote carcinogenesis. NAFLD is now considered the hepatic manifestation of metabolic syndrome (MS) and the latter, as demonstrated by numerous studies, represents a condition that increases the risk of cancer, especially of the gastrointestinal tract. Colorectal cancer (CRC) has thus far been consistently associated with NAFLD. The mechanisms that associate NAFLD with the risk of developing cancer are not yet fully understood, but probably derive from the bidirectional relationship between NAFLD and metabolic syndrome. NAFLD and visceral adipose tissue represent major parts of the central obesity axis.