Vulvar papillary hidradenoma arises from specialized anogenital apocrine glands in and around the intralabial sulcus. These are benign lesions, which appear as limited, slow-growing cystic masses, especially in reproductive age. Here we discuss a case of papillary hydroadenoma of the vulva in a young woman. IntroductionVulvar lesions are classified based on the tissue of origin. These can be hidradenoma, syringoma, condyloma acuminata and acrochordon which are of epithelial origin; leiomyoma, lipoma, fibroma, neurofibroma and granular cell tumor of mesenchymal origin; and hemangiomas and lymphangiomas of vascular origin. Say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essay Glandular blockage causes Bartholin's cysts. Rare lesions such as endometriosis can also occur. It is important to distinguish a benign lesion such as hidradenoma from a rare hidradenocarcinoma or even an aggressive malignancy such as Merkel cell cancer for appropriate treatment, follow-up and patient counseling. The term hydroadenoma denotes the tumor of the sweat gland. Papillary hidradenoma is a rare, benign, cystic tumor of the sweat glands. This was originally reported in adult Caucasian women. It derives from the anogenital glands, with apocrine differentiation. Estrogen and progesterone receptors are present in anogenital sweat glands and are markers to differentiate these glands from other usual sweat glands. Due to the positivity of estrogen and progesterone receptors, it is believed that hormonal stimulation may play a role in the pathogenesis of hidradenomas in women. Our patient did not have any hormonal abnormalities. Androgen receptor positivity in some papillary hidradenomas is documented in luminal cells. This has similarities to proliferative disorders of the breast. Therefore, hidradenomas are believed to grow in specialized anogenital glands around the intralabial sulcus, which is located in the mammary line. These tumors are mostly single, small, and cause no symptoms. Most lesions occur in the labia majora, appearing as a raised mass. It usually takes on the color of the overlying skin. The incidence of multiple lesions is estimated at around 5%. Our patient presented with swelling with typical description, as described in the literature, but had a single swelling. Ectopic papillary hidradenoma is slightly more common in women and can be seen in any age group. Ectopic papillary hidradenoma can occur at any location, including the head and neck region, extremities, external ear, upper eyelid, and chest wall. The differential diagnosis includes the conditions mentioned above but, rarely, a neoplasm. Our patient had no other similar swellings. Please note: this is just a sample. Get a custom paper from our expert writers now. Get a custom essay. Vazmitel et al. reported a case of ductal carcinoma in situ arising from papillary hydroadenoma, with association with human papilloma virus 16. Kazakov et al in their study of 18 cases found human papilloma virus particles in four cases. Some cases had multiple strains. However, a causal association has not been established. HPV was not tested in our patient. Simple surgical excision is adequate for treatment. When a Bartholin cyst coexists, wide surgical excision may be considered. Close follow-up is recommended as the recurrence rate is not clearly known..