Congenital Insensitivity to Anhidrosis (or CIPA) is a rare genetic disorder with the characteristics of not being able to feel any pain or fever and little or no sweating. It is inherited in an autosomal recessive manner, meaning that both parents have a mutated NTRK1 gene, but do not show any symptoms of CIPA. The damaged NTRK1 gene produces proteins that cannot transmit signals. Since neurons do not receive any signals from proteins, they perform apoptosis. Apoptosis is a process by which neurons self-destruct. Without these sensory neurons, people with CIPA cannot feel any pain or fever. They also lose nerves to their sweat glands, which leads to anhidrosis – reduced or no sweating. The purpose of this document is to inform you about what CIPA is, what support is available to those who have it, and what research is being done into it. I chose to write about CIPA because I thought it was interesting and wanted to learn more. Congenital insensitivity to pain with anhidrosis is a genetic disorder inherited in an autosomal recessive pattern. This means that both parents have a damaged NTRK1 gene and pass it on to their offspring. They themselves show no signs of CIPA, but this combination of the damaged genes activates it for their children and mutates eleven genes, which can lead to diseases. Since the NTRK1 gene is supposed to produce proteins needed for neurons (nerve cells) to develop and survive, but it is damaged, it produces proteins that do not transmit signals (usually related to temperature, pain and touch ). CIPA is a disease that involves not being able to feel pain or fever. People with CIPA also suffer from anhidrosis, the ability to sweat little or not at all....... half of the article ......Orphanet Journal of Rare Diseases. BioMed Central Ltd. Web. 29 January 2014. .Inouye, Danish. "Congenital insensitivity to pain with anhidrosis". Honohu ​​6.4 (2008): no. page University of Hawai'i at Hilo Campus Center. University of Hawai'i at Hilo, 2008. Web. January 30, 2014. .McKusick, Victor A. "OMIM Entry # 256800 - INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHYDROSIS; CIPA." Online Mendelian inheritance in humans (OMIM). Ed. Cassandra L. Kniffin. Johns Hopkins University, May 21, 2009. Web. January 30, 2014. Location of .NTRK1 on a chromosome. Nd Photography. Genetics Home Reference. Genetics Home Reference, 27 January 2014. Web. 29 January. 2014. .